Expressions of FHIT in patients with endometriosis
SUNHong-mei
SONG Rong-rong
Abstract：Objective To observe the expression of fragile histidine triad (FHIT) protein in the endometriosis and its significance. Methods 28 pairs of samples of endometrium and ectopic endometrium from endometriosis (EMT) patients (EMT group), and 28 endometrial samples from patients only with myoma of uterus (control group)were tested for the expression of FHIT by immunohistochemical SP method. Results FHIT was mainly expressed in the cytoplasm and membraneof endometrial glandular epithelial cells. The positive rate of FHIT expression in endometriumand ectopic endometrium from intrauterine membrane endometriosis (EMT group) patientwas 68% and 54%, which had no significant difference (P > 0.05). However, the positive rate of FHIT expression in control group was 96% (27/28), which is higher than those in the EM group, and the differences were statistically significant. The expression of FHIT was different indifferent stages of r-AFS in ectopic endometrium samples. The expression in stage Ⅰ-Ⅱ is higher than in stage Ⅲ-Ⅳ, with statistical significance. Conclusions FHIT may have some correlation with the development of endometriosis , and may have some influence on the severity of this disease.
Keywords：EndometriosisFragile histidine triadImmunohistochemistry
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2660-2662 )