Serum vitamin D levels in patients with systemic lupus erythematosus and their relationship with disease activity
LU Qin-yan
CAI Xiao-yan
LIN Xiao-jun
TANG Chun
YE Jin-hua
LI Wei-nian
HE Zhi-xiang
LI Xin-ying
ZHANG Rong-wei
Abstract：Objective To detect the serum 25- OH-D levels in patients with systemic lupus erythematosus (SLE) and investigate the function of vitamin D in the pathogenesis of SLE. Methods Eighty SLE patients including 40 healthy donors and 40 RA (rheumatoid arthritis) patients were enrolled in this study. Serum 25-OH-D levels were detected with ECL method. Results (1)Serum 25-OH-D levels in patients with active SLE were lower than those with inactive SLE patients and healthy controls. (2)Serum 25-OH-D levels were negatively correlated with SLEDAI (Systemic Lupus Erythematosus Disease Activity Index) scores (r = -0.45,P < 0.01) and 24-hours urinary protein excretion (r = -0.32,P < 0.05). Conclusion Serum 25-OH-D levels in SLE patients decrease and have close relationship with disease activity and renal lesions.
Keywords：Systemic lupus erythematosus25-OH-Delectrochemiluminescence
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1123-1125 )