Expression of SOX2 and TGF-β1,Smad3 in gastric carcinoma and their relation

LI Chun-hui; PAN Li-hui; LIU Hai-wang; CHENG Yu

doi:10.3969/j.issn.1006-5725.2015.05.018

Abstract：Objective To investigate the expression of SOX2,TGF-β1 and Smad3 in gastric cancer and their relationships with clinical pathological characteristics of gastric cancer. Methods Immunohistochemical staining was used to detect the expression of SOX2, TGF-β1 and Smad3 expression and the clinical pathological characteristics of gastric cancer were analyzed. Results Integrated optical density (IOD) values from the positive expression of SOX2, Smad3 in gastric cancer group were all significantly lower than normal gastric tissues (P < 0.05). IOD values from the positive expression of TGF-β1 in gastric cancer group were all significantly higher than normal gastric tissues (P < 0.05). IOD values from the positive expression of TGF-β1 in lower poorly differentiated gastric cancer tissues, with lymph node metastasis and Ⅲ+Ⅳ were all significantly higher (P < 0.05). Higher IOD values from expression of SOX2 and Smad3 were found in high-moderated differentiated gastric cancer tissues, without lymph node metastasis and Ⅰ+Ⅱgastric cancer (P < 0.05). SOX2, TGF-β1 and Smad3 in gastric cancer has nothing to do with age illness and sex (P >0.05). There was positive correlation between SOX2 and Smad3 expression in gastric cancer tissues, and negative correlation between TGF-β1 and Smad3 in gastric cancer. Conclusions Abnormal expression of SOX2, TGF-β1 and Smad3 protein is related to the onset, development and clinicopathologic features of gastric cancer.