Impact of G6PD deficiency on plasmodium falciparum malaria
CHEN Jiang-tao
LIN Min
LIU Pei-fen
ZHONG De-shan
XIE Dong-de
Santiago-m Monte-Nguba
Juan Carlos Salas Ehapo
Urbano Monsuy Eyi
YANG Li-ye
YANG Hui
ZHAN Xiao-fen
YANG Hui-tian
Abstract：Objective To investigate the impact of Glucose-6-phosphate dehydrogenase (G6PD) deficiency on plasmodium falciparum malaria. Methods A cross-sectional study was performed on 2 690 patients in Malabo regional hospital on Bioko Island during rainy season (2012). The plasmodium falciparum was identified by real-time PCR and oil immersion microscopy. G6PD deficiency was identified by a fluorescent spot test (FST) and PCR-DNA sequencing. Logistic regression was conducted to estimate the association between G6PD deficiency and malaria. Results The prevalence of G6PD was 9.22% in the population , all of whose genotype G6PD deficiency was G6PD*A-(c.202 G > A/c.376 A > G). Confounding factors-adjusted OR showed that G6PD deficiency provided significant protection against malaria (P < 0.05). It was found that male hemizygotes has a protective effect against malaria (P < 0.05), while the female heterozygote group and female homozygous group had no statistical difference (P > 0.05). Conclusions The results suggest that male hemizygotes could provide protection against malaria. Further studies are required to explore the molecular mechanism in malaria infection.
Keywords：MalariafalciparumGlucose-6-phosphate dehydrogenase deficiencyCross-sectional study
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3418-3421 )