Effect of motivation of EPCs by G-CSF on cardiac function in patients with myocardial infarction
LIANG Shao-lan
DU Zuo-yi
LI Zi-cheng
JIN Wen
Abstract：Objective To observe the effect of motivation of endothelial progenitor cells (EPCs) by granulocyte colony-stimulating factor (G-CSF) on cardiac function in patients with myocardial infarction (MI). Methods Eighty MI patients were sellectedand then were divided into a conventional treatment group (n = 40) and a EPC motivation group (n = 40). EPCs were detected by flow cytometry. Results The rate of EPCs was increased from (0.11 ± 0.04)% in the baseline to (5.32 ± 1.06)% (P < 0.05). Before treatment, 6MWT, LVEF, and LVEDD did not differ significantly between the conventional treatment group and the EPC motivation group (P > 0.05); after treatment, 6MWT, LVEF, and LVEDD were significantly increased in both groups (P < 0.05 and P < 0.01). However, 6MWT, LVEF, and LVEDD were higher in the EPC motivation group than in the conventional treatment group (P <0.05). The clinical effectiveness rate was higher in the EPC motivation group than in the conventional treatment group (90.0% vs. 75.0%, P < 0.05). There was no significant difference between the two groups in adverse reactions (7.5%vs. 10.0%, P > 0.05). Conclusions G-CSF can markedly motivate EPCs, which is beneficial for improvement of cardiac function in MI patients.
Keywords：Myocardial infarctionGranulocyte colony-stimulating factorEndothelial progenitor cells
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2759-2761 )