Study on the role of interleukin 6, matrix metalloproteinases 2 in the first trimester
CUI Shi-hong
ZHAO Lan-lan
CAI Yi-ming
YANG Pei-feng
ZHANG Lin-dong
HAN Xiao
LIU Bo
Tao Bei-bei
YU Hai-yang
Abstract：Objective To explore the relationship between the Interleukin 6 , matrix metalloproteinases 2 and early embryo arrest. Methods Real time-PCR was used to measure the mRNA expression of IL-6 and MMP-2 and immunohistochemistry (IHC, SP method)was used to measure the location and expression of the two different kinds of protein in villus. ELISA was used to measure the level of IL-6 in serum. Results Real-time PCR and IHC showed that the expression levels of IL-6 was significantly lower in experimental group than in control group, and MMP-2 was significantly higher than the control group (P < 0.05). Differenc of IL-6 level in serum between the two groups was not statistically significant (P > 0.05). Conclusion Proper expressions of IL-6 and MMP-2 in the villus tissue play a key role in the maintenance of early pregnancy.
Keywords：Interleukin-6Matrix metalloproteinase-2Immunologic balanceEarly embryo arrest
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 905-908 )