Evaluation of combination therapy with vitamin E and vitamin C for idiopathic asthenospermia by Q value method
HAN Peng
LIU Zhi-wen
ZHANG Guo-gang
XIAO Shou-yun
XU Hong
WANG Jiu-lin
Abstract：Objective To use Q value method to assess the effect of combination therapy with vitamin E and vitamin C for idiopathic asthenospermia. Methods 76 patients diagnosed as idiopathic asthenospermia by computer-assisted semen analysis according to the WHO criteria were selected at the andrology clinic from August 2012 to November 2013. Malondialdehyde (MDA) concentration was measured by using thiobarbituric acid (TBA) assay. The patients were randomly divided into three groups. Vit C group received vitamin C 200 mg thrice daily, vit E group received vitamin E 100 mg thrice daily , and the combination group received vitamins E and C for 12 weeks. Repeat semen analysis and MDA measurement were conducted after treatment, and the Q value which evaluated whether a synergistic interaction existed was calculated. Results MDA concentration decreased in all the groups, with the lowest concentration in the combination group. While all the groups achieved improvement in term of progressive motility , with the combination group presented far more better than the other two groups , exhibiting a synergistic interaction, with a Q value of 1.18. Conclusion Combination therapy with vitamin E and vitamin C has a marked internal synergistic effect on antioxidation in the treatment of idiopathic asthenospermia.
Keywords：AsthenozoospermiaVitamin EVitamin CReactive oxygen speciesMDASynergistic interactionQ value
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 738-741 )