Relationship between serum uric acid levels and insulin resistance and risk factors screening for high serum uric acid in patients

YIN Guo-shu; XU Dong-chuan; SUN Ru-qiong; WANG Ping

doi:10.3969/j.issn.1006-5725.2014.03.024

Abstract：Objective To compare the levels of serum uric acid in three groups of patients with different glucose tolerance status, and to investigate the relationships between serum uric acid and insulin resistance and to screen the risk factors for high serum uric acid in patients. Methods 99 patients with normal glucose tolerance (NGT group), 76 patients with impaired of glucose tolerance (IGT group) and 72 patients with T2DM (T2DM group) were enrolled in this study. Levels of serum aldosterone, serum uric acid concentration and plasma renin activity (PRA) were determined in all patients. Fasting plasma glucose concentration and plasma glucose concentration after glucose load, fasting serum insulin concentration and serum insulin concentration after glucose load were determined in 132 participants. The levels of serum uric acid concentration were compared among the three groups of patients. Correlation coefficients between serum uric acid concentration and serum insulin concentration as well as HOMA-IR were studied according to the Pearson analysis. The affecting factors for high serum uric acid concentration were screened by multiple liner regression analysis. Results The levels of serum uric acid concentration were higher in the T2DM group than those in the NGT group, with no statistical difference with those in the IGT group. Serum uric acid concentration was positively correlated with serum insulin level, including fasting and after glucose lord, and Log-HOMA-IR, with the correlation coefficient index 0.28 (P < 0.01), 0.222 (P < 0.01) and 0.242 (P < 0.01), respectively. The affecting factors for high serum uric acid concentration were PRA, BMI, creatinine and serum sodium concentration with the β value 0.167 (P < 0.05), 0.314 (P < 0.01), 0.175 (P<0.01) and 0.161 (P<0.05), respectively. Conclusions The level of serum uric acid increased in the patients with type 2 diabetes is positively correlated with insulin resistance. The risk factors for high serum uric acid are PRA, BMI, serum creatinine concentration and serum sodium concentration.