The clinical significance of serum S-100B and neuron-specific enolase of craniocerebral injury in children with severe hand foot and mouth disease
LE Gao-zhong
WU Xiao-yang
WEN Ru-quan
D0NG Xiang-yu
Abstract：Objective To explore the level of S-100B and neuron-specific enolase (NSE) in the serum of craniocerebral injury and their clinical significance in children with severe hand foot and mouth disease (HFMD). Methods The serum levels of S-100B and NSE were determined by enzyme linked immunosorbent assay (ELISA). 58 children with severe HFMD from June to December in 2012 in our hospital were selected as the study group, in which 40 cases were severe type, 18 cases of critical type, including 3 cases of deaths. At the same time, 39 cases with mild type HFMD were selected as the control group, 30 cases from the outpatient health check-up children as the normal control group. There were no significant statistical difference in age and gender of the three groups (P > 0.05). The relationship of serum S-100B and NSE of craniocerebral injury in children with severe HFMD and the prognosis was analyzed. Results (1) Compared with the two control groups, the S-100B and NSE level in study group were significant different (P < 0.01). (2) Compared with the mild type of HFMD, the S-100B and NSE level in the normal control group were not significant statistical different (P >0.05). (3) Compared with the severe type of HFMD, the S-100B and NSE level in the critical type group were significant statistical different (P < 0.05). (4) There were significant statistical difference in the S-100B and NSE level between before and after treatment in Children with severe HFMD (P < 0.05). Conclusion The serum level of S-100B and NSE could reflect the severity of the craniocerebral injury of severe HFMD and may serve as two important indexs of predicting the prognosis in children with severe HFMD.
Keywords：Handfoot and mouth diseaseS-100BNeuron-specific enolaseHead injuryEvaluation of prognosisChildren
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 412-415 )