Correlation between plasma homocysteine levels and blood glucose fluctuation coefficient in elderly patients with short-term diabetes mellitus
LI Ying
LIANG Xin-hua
AN Na
WANG Min-zhe
Abstract：Objective To investigate the correlations between plasma homocysteine levels (Hcy) and blood glucose fluctuation coefficient in elderly patients with short-term (less than 5 years) type 2 diabetes mellitus (T2DM). Methods Eighty seven elderly type 2 diabetic inpatients with a course of 5 years were eligibly recruited. Hcy was measured using biochemical detection. All of them underwent Guardian RT continuous glucose monitoring system (RT-CGMS). According to blood sugar fluctuation coefficient (S),the patients were divided into three group: S≤1.5 (S1 group), 1.5 < S ≤ 2.0 group (S2 group) and S > 2.0 group (S3 group). The general data of the three groups and biochemical indicators were observed and analyzed. The risk factors associated with blood glucose fluctuations were analyzed by Logistic regression analysis. Results Average blood glucose fluctuation (MAGE), standard deviation for 24 h blood glucose level (SDBG), 24 h biggest blood glucose swings (L-AGE), the average value of volatility postprandial blood sugar (M-PPGE) were closely related to blood sugar fluctuation coefficient (S) (P < 0.01). The levels of plasma Hcy in S2 and S3 group were significantly higher than that in S1 group (P<0.05). The cases receiving insulin treatment in S2 and S3 group were significantly more than that in S1 group (P < 0.017). The levels of triglyceride in S2 and S3 group were significantly higher than that in S1 group (P < 0.05). Homocysteine levels, age and insulin treatment were related independently and significantly with fluctuation by multivariate Logistic regression analysis. Conclusion Blood sugar fluctuation coefficient can be accurate for the assessment of blood sugar fluctuations and plasma homocysteine levels can be used as a predictor of blood sugar fluctuations in elderly patients with type 2 diabetes mellitus.
Keywords：Diabetes mellitustype 2ElderlyHomocysteine levelBlood glucose fluctuation coefficient
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 402-405 )