Application of pepsin detection in nasal cavity and pH monitoring in the diagnosis of larynghopharyngeal reflux
JIN Ri-qun
LIAO Zhi-ying
PENG Shao-ping
LIU Jia-feng
YOU Ling-yun
XIE Yang
XIONG Yi-hao
Abstract：Objective To explore the application of pepsin detection in nasal cavity and pH monitoring in the diagnosis of larynghopharyngeal reflux (LPR). Methods Fifty patients with CRS and 20 healthy volunteers were recruited. They received 24-hour pH monitoring in larynghopharyngeal and pepsin detection in nasal cavity by enzyme -linked immunoabsorbent assay (ELISA). Results The LPR incidence rate in CRS patients by 24-hour pH monitoring was significant higher than that in healthy volunteers group (P < 0.01)(84%, 25%, respectively). The pepsin positive rate was significant higher than that in healthy volunteers group (P < 0.01)(88%, 30%, respectively). The pepsin concentration in nasal secretions was used in the diagnosis index of LPR, the sensitivity, specificity, misdiagnosis rate and the missed diagnosis were 88%, 70%, 30%, 12%, respectively. The method was well consistent with the examination of pH monitoring (Kappa>0.75, P<0.01). Conclusion The examination of pepsin in nasal secretions may provided believable indicator for the diagnosis of LPR.
Keywords：SinusitisLarynghopharyngeal refluxPepsinpH monitoring
Publication Date：2014-01-31
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 400-402 )