Apocrine Cystadenoma of the Face:a Case Report
WANG Zhihan
YANG Dingquan
HUANG Chuhan
HE Zhihong
ZHONG Shiyi
LIU Qingwu
Abstract：We present a case of apocrine cystadenoma of the face.The patient was a 51-year-old man who presented with a pigmented lesion on the left zygomatic area that had been present for several years and had enlarged with ulceration over the past three years.On examination,there was a well-circumscribed,firm,smooth,black cutaneous nodule measuring approximately 1.0×0.7×0.4 cm on the left zygoma.Hematoxylin and eosin(HE)revealed multiple intact cystic spaces in the dermis;portions of the cyst wall showed papillary projections into the lumen,and luminal contents exhibited characteristic apocrine decapitation secretion.Findings were consistent with apocrine differentiation.Immunohistochemical profiling showed focal positivity for cytokeratin 5/6(CK5/6),p63 positivity in basal cells,CK8/18 positivity,partial epithelial membrane antigen(EMA)expression,Ki-67 labeling of about 5%,wild-type p53 expression,and negative α-smooth muscle actin(α-SMA).Special stains were alcian blue-periodic acid schiff(AB-PAS)and diastase periodic acid-schiff(D-PAS)positive,supporting the presence of apocrine secretory material.A diagnosis of apocrine cystadenoma was made.The lesion was completely excised surgically,and the patient was followed up through February 2025 without evidence of recurrence.
Keywords：apocrine glandscystadenomaskin tumourscase report
Publication Date：2026-02-10
Online Publishing Date：2026-03-17(First online date of this platform, not the publication date of the document)
Pages：3( 89-91 )