Research Advances in Signal Transduction Pathways of Melanocytes Associated with Vitiligo
PING Bei
WANG Wenxin
ZHU Haijun
Abstract：Vitiligo is a prevalent autoimmune skin disorder with a multifaceted pathogenesis involving genetic,immunological,and environmental factors.It manifests as progressive depigmentation of the skin,mucous membranes,and hair.Melanocytes,as pivotal cells in pigment production,play an essential role in the repigmentation of vitiligo lesions.Their survival,differentiation,and migration are intricately governed by various signal transduction pathways.The pathogenesis of vitiligo is closely associated with imbalances in melanocyte signaling regulation at multiple levels,including the Wnt/β-catenin,microphthalmia-associated transcription factor(MITF),sex determining region Y-box 10(Sox10),Notch,transforming growth factor-β(TGF-β),and stem cell factor(SCF)/c-Kit pathways.Dysregulation in these pathways not only directly impairs melanocyte function but also exacerbates the disease through immune system modulation.This article systematically summarized the mechanisms of multiple melanocyte signaling pathways in the onset of vitiligo,thus providing new ideas for the treatment of vitiligo.
Keywords：vitiligomelanocytesignal transductionmechanismreview
Publication Date：2025-12-10
Online Publishing Date：2026-01-04(First online date of this platform, not the publication date of the document)
Pages：8( 452-458,464 )