Clinical Efficacy of Microneedling Combined with Ectoin Liquid Dressing for M+V Type Melasma

ZHANG Yitian; WANG Yanting; ZHOU Ming; GUO Qiaona; LIU Chengbo

doi:10.11786/sypfbxzz.1674-1293.20250607

Abstract：Objective To explore the clinical effect of microneedling combined with ectoin liquid dressing for M+V type melasma.Methods Twenty patients with M+V type melasma who visited the Medical Cosmetic Center of Xi'an International Medical Center Hospital from September 2022 to December 2023 were recruited in the self-controlled clinical trial.All patients were managed by 0.5mm microneedling combined with Ectoin liquid dressing for 3 months(qm).They were scored by melasma area and severity index(MASI)and physician's global assessment(PGA)with VISIA images at baseline,at the termination of treatment,and 3-months follow-up.The PIMIA software was used to analyze the percentage of pigmented area,macular pigment optical density(MPOD)values,and red zone a* value(reflecting the degree of erythema).Results All patients completed treatment.MASI scores at the termination of treatment and 3-months follow-up were significantly decreased compared with the pre-treatment(6.26±3.27,5.28±2.89 vs 9.56±5.98,all P<0.001).At the termination of treatment,there were 4 patients with a PGA score of 1(essentially eliminated,≥90%),7 patients with a score of 2(markedly improved,75%-89%),7 patients with a score of 3(moderately improved,50%-74%),and 2 patients with a score of 5(non improved,＜25%),giving an overall treatment efficiency of 90%.The percentage of pigmented area,MPOD values,and the red zone a* value were significantly lower at the termination of treatment and 3-months follow-up compared with at the baseline(all P<0.05).All patients had mild erythema and edema within 1-3 days after treatment,which resolved on their own without treatment.None of the patients had serious adverse reactions.Conclusion Microneedling combined with Ectoin liquid dressing can effectively improve the therapeutic efficacy of M+V type melasma with a high safety.