Clinical Efficacy of CO2 Fractional Laser Combined with Tranexamic Acid for Patients with Seborrheic Keratosis in the Plateau Area
HU Yan
XU Menyuan
PENG Shuiping
ZHAO Yan
Abstract：Objective To observe the clinical effect of CO2 fractional laser combined with tranexamic acid in the treatment of patients with seborrheic keratosis(SK)in plateau areas.Methods A total of 152 SK patients in the plateau area admitted to the Department of Dermatology of People's Hospital of Aba Tibetan and Qiang Autonomous Prefecture from October 2024 to January 2025 were randomly assigned into control group(n=76)and the observation group(n=76)by the random number table method.All patients were managed by CO2 fractional laser,and those in the observation group were additionally treated with tranexamic acid.Treated for two months,the aim was to compare the recovery conditions(time to scab shedding and to erythema regression),skin physiological indicators(trans epidermal water loss[TEWL]measurements,stratum corneum water content),and dermatology life quality index(DLQI)score.The clinical efficacy and the incidence of adverse reactions were assessed.Results The overall effective rate in the observation group was significantly higher than that in the control group(94.74%vs 69.74%,P<0.05).The time to scab shedding and to erythema regression in the observation group were significantly shorter than those in the control group(P<0.05).After treatment,significantly decreased TEWL measurements,and increased stratum corneum water content were detected in the two groups(all P<0.05),which were significantly pronounced in the observation group(all P<0.05).After treatment,the total DLQI score in the both groups was significantly decreased compared with before treatment,which was significantly lower in the observation group than in the control group(P<0.05).None of the total incidence of adverse reactions differed significantly between observation group and control group(15.79%vs 14.47%,P>0.05).Conclusion In the plateau area,CO2 fractional laser combined with tranexamic acid can effectively increase the total clinical effective rate for SK patients,shorten the time for scab shedding and erythema regression,improve skin barrier function and quality of life,and without increased adverse reactions.
Keywords：seborrheic keratosisplateau areatranexamic acidCO2 fractional lasercomparative study of curative effectquality of life
Publication Date：2025-12-10
Online Publishing Date：2026-01-04(First online date of this platform, not the publication date of the document)
Pages：6( 420-424,429 )