Serum Matrix Metalloproteinase Levels in Bullous Pemphigoid Patients and Their Association with Disease Activity
DING Cheng
ZHANG Haixiang
ZHAO Zishen
QIN Lanying
Abstract：Objective To detect serum matrix metalloproteinase(MMP)levels in patients with bullous pemphigoid(BP)and their association with disease activity.Methods A total of 60 BP patients treated in Cangzhou People's Hospital from April 2021 to April 2022 were selected as the BP group,and 60 healthy subjects during the same period were recruited as the healthy group.Serum MMP-2,MMP-9,MMP-11 and MMP-13 levels were compared between the two groups.According to the disease activity of BP patients,they were divided into the non-bullous stage group(n=32)and bullous stage group(n=28).Serum MMP-2,MMP-9,MMP-11 and MMP-13 in BP patients with non-bullous stage and bullous stage were compared and analyzed,and their correlation with disease activity was also analyzed by Pearson correlation analysis.A diagnostic model was constructed.The diagnostic efficacy of MMP-2,MMP-9,MMP-11 and MMP-13 in non-bullous stage of BP was evaluated by the receiver operating characteristic(ROC)curves.Results Serum MMP-2,MMP-9,MMP-11 and MMP-13 levels in the BP group were significantly higher than those of the healthy group(P＜0.05),and they were significantly lower in the non-bullous stage group than the bullous stage group(P＜0.05).Pearson correlation analysis showed that serum MMP-2,MMP-9,MMP-11 and MMP-13 levels were positively correlated with the disease activity(P＜0.05).A logistic regression model for predicting the activity of BP was created as follows:Logit(P)=-20.973+0.341×MMP-2+0.260×MMP-9+0.267×MMP-11+0.206×MMP-13.ROC curve analysis results showed that the area under the curve(AUC)of the combination of serum MMP-2,MMP-9,MMP-11 and MMP-13 levels was 0.872,which was larger than the AUC of the single indicator with good sensitivity and specificity.Conclusion Serum MMP-2,MMP-9,MMP-11 and MMP-13 levels significantly increase in BP patients,and closely related to the disease activity,which has good diagnostic efficacy in non-bullous patients.
Keywords：bullous pemphigoidmatrix metalloproteinasesdisease activitycorrelation
Publication Date：2025-12-10
Online Publishing Date：2026-01-04(First online date of this platform, not the publication date of the document)
Pages：5( 415-419 )