Detection of sTARC and serum SCCA2 levels in patients with atopic dermatitis and their clinical significance
YANG Yu
XIONG Lingling
DU Xiujun
CHEN Ying
ZHAO Juhua
Abstract：Objective To detect serum levels of soluble thymus and activation-regulated chemokine(sTARC)and squamous cell carcinoma antigen 2(SCCA2)in patients with atopic dermatitis(AD),and analyze their clinical significance.Methods A total of 148 AD patients treated in the Department of Dermatology and Venereology,Nanchong Hospital of Beijing Anzhen Hospital Affiliated to Capital Medical University(Nanchong Central Hospital)from March 2022 to March 2024 were enrolled as the case group,with 100 healthy volunteers from the same hospital during the same period as the control group.Serum sTARC and SCCA2 levels were compared between the two groups,as well as before and after treatment in AD patients.AD patients were stratified into mild-to-moderate(n=106)and severe(n=42)groups according to the SCORAD index.Clinical data,sTARC,and serum SCCA2 levels were compared between groups.Logistic regression was used to analyze risk factors for AD severity,Pearson test to explore correlations between sTARC/SCCA2 levels and SCORAD scores,and receiver operating characteristic(ROC)curves to evaluate the predictive value of serum sTARC and SCCA2(alone and in combination)for severe AD.Result Compared with the control group,serum sTARC and SCCA2 levels were significantly higher in the case group(P<0.05).In the case group,sTARC and SCCA2 levels decreased significantly at 1,4,and 8 weeks after treatment compared with baseline(P<0.05).The severe group showed higher eosinophil percentage,SCORAD scores,sTARC,and SCCA2 levels than the mild-to-moderate group(P<0.05).High eosinophil percentage,high SCORAD score,high sTARC,and high SCCA2 were identified as risk factors for severe AD(P<0.05).Pearson analysis showed positive correlations between serum sTARC/SCCA2 levels and SCORAD scores(P<0.05).The combined detection of sTARC and SCCA2 achieved a sensitivity of 0.833 3,specificity of 0.754 9,and area under the curve(AUC)of 0.849 for predicting severe AD.Conclusion Serum sTARC and SCCA2 levels reflect AD progression,with their high expression associated with disease severity.Combined detection of sTARC and SCCA2 demonstrates high predictive value for severe AD.
Keywords：DermatitisatopicSerum thymus and activation regulatory chemokinesSquamous cell carcinoma antigen 2Severity of illnessCorrelationROC Curve
Publication Date：2025-08-10
Online Publishing Date：2025-09-01(First online date of this platform, not the publication date of the document)
Pages：5( 261-265 )