Analysis of serum squamous cell carcinoma antigen levels in patients with psoriasis vulgaris
LI Yiman
DENG Danqi
Abstract：Objective To analyze the correlation between serum squamous cell carcinoma antigen(SCCA)levels and psoriasis vulgaris.Methods Basic clinical data and laboratory results were collected from 58 patients with psoriasis vulgaris,61 with atopic dermatitis,and 78 healthy controls.Differences in SCCA levels and other markers were compared among the three groups.Psoriasis patients were reassessed after 3 months of treatment to evaluate changes in SCCA and other parameters.Results Both psoriasis and atopic dermatitis groups exhibited significantly higher SCCA levels and a higher incidence of abnormal SCCA elevation than the healthy control group(P<0.05).Additionally,the psoriasis group showed higher rates of proteinuria(PRO),elevated carcinoembryonic antigen(CEA),and cytokeratin 19 fragment(CYFRA21-1)compared to controls(P<0.05).Following treatment,psoriasis patients demonstrated significant decreases in SCCA levels,white blood cell(WBC)count,and Psoriasis Area and Severity Index(PASI)scores,alongside increases in total protein(TP)and albumin(Alb)(P<0.05).Multivariate linear regression analysis revealed a significant positive association between PASI scores and SCCA levels.Conclusion Serum SCCA levels are elevated in both psoriasis vulgaris and atopic dermatitis,with a higher incidence of abnormal elevation compared to healthy individuals.PASI scores correlate positively with SCCA levels,and treatment of psoriasis leads to a significant reduction in SCCA levels.
Keywords：PsoriasisvulgarisDermatitisatopicAntigensquamous cell carcinoma
Publication Date：2025-08-10
Online Publishing Date：2025-09-01(First online date of this platform, not the publication date of the document)
Pages：5( 246-250 )