Clinical study on 42 cases of chronic urticaria with elevated IgE treated by press needles combined with desloratadine citrate disodium

LI Ran; XIONG Lingling; CHEN Ying

doi:10.11786/sypfbxzz.1674-1293.20250105

Abstract：Objective To explore the clinical effi cacy of press needles combined with desloratadine citrate disodium in the treatment of chronic urticaria with elevated IgE.Methods A total of 84 patients diagnosed with chronic urticaria with elevated IgE in department of dermatology of Nanchong Central Hospital from July 2021 to July 2022 were selected as subjects and then randomly divided into a treatment group with 42 cases and a control group with 42 cases.All patients were orally administered desloratadine citrate disodium tablets for treatment.The 42 cases in the treatment group were additionally treated with press needles.The clinical efficacy,the 7-day Urticaria Activity Score(UAS7),the levels of interferon-γ(IFN-γ),immunoglobulin E(IgE),and interleukin-4(IL-4)in the serum,as well as the adverse reactions were evaluated and observed between the two groups before and after the treatment.Finally,one month after the end of the treatment,a follow-up was conducted to evaluate the recurrence rates o f the two groups.Results The effective rate of the treatment group(83.33％)was significantly higher than that of the control group(53.76％)(P＜0.05).Four weeks after the treatment,the scores of UAS7,and the serum levels of IL-4 and IgE in both groups decreased significantly(P＜0.01),and the values in the treatment group were even lower than those in the control group(P＜0.05).After the treatment,the serum level of IFN-γ increased in both groups(P＜0.01),and the level in the treatment group was higher than that in the control group(P＜0.05).In the treatment group,4 cases experienced dizziness and 1 case had discomfort in the upper abdomen.In the control group,3 cases presented with dizziness.The recurrence rate of the treatment group(17.14％)was notably lower than that of the control group(43.48％).Conclusion The combination of press needles and desloratadine citrate disodium has a definite curative effect in the treatment of chronic urticaria with elevated IgEand can improve the immune status of patients.