Multiple active nodules of extremities were the main manifestations of lipomembranous fat necrosis complicated with calcinosis cutis:a case report
ZHAO Mi-mi
LIU Ting-ting
LU Qing-lian
Abstract：The patient is a 59-year-old female presented with repeated erythema and nodules on both legs with pain for one year,which aggravated over the last 6 months.Dermatological examination showed that scattered reticular and patchy erythema,telangiectasia and pigmentation on both legs.Several subcutaneous nodules,ranging from the size of soybeans to broad beans,were palpable on the limbs.These nodules were mobile,hard and tender,with no surface ulcers.The surface skin appeared normal.Histopathological examination of the nodules showed epidermal atrophy,dermal edema,and focal necrosis of subcutaneous fat with calcium salt deposition.The fat membrane exhibited a feathery appearance and protruded into the microcapsules of the fat membrane.No cercariae of parasites were observed.The diagnosis was lipomembranous fat necrosis complicated with calcinosis cutis.After 6 months of treatment with thalidomide(50 mg three times daily)and total glucosides(0.6 g twice daily),some nodules subsided,and the patient experienced relief from pain.
Keywords：PanniculitisFat necrosisCalcinosis cutis
Publication Date：2023-12-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 377-379 )