The expression of Bcl-6,Bim,PUMA,BNIP3 and BNIP3L in psoriasis and normal human skin
LI Ying
ZHANG Xiao-yan
Abstract：Objective To investigate the significance of the expression of apoptosis-related factors Bcl-6,Bim,PUMA,BNIP3 and BNIP3L downstream of FOXO in the pathogenesis of psoriasis vulgaris.Methods 31 patients with psoriasis vulgaris and 30 cases of normal control were selected.The immunohistochemistry method was used to detect the expression of Bcl-6,Bim,PUMA,BNIP3 and BNIP3L.The expression levels of Bcl-6,Bim,PUMA,BNIP3 and BNIP3L were analyzed by measuring the average optical density of immunostaining.Results Immunohistochemical analysis revealed that the expressions of Bcl-6 and BNIP3 in psoriasis vulgaris lesions were significantly higher than those in normal skin(P＜0.001);The expression of Bim was significantly lower than that of normal skin(P＜0.001);The expressions of both PUMA and BNIP3L in psoriatic lesions showed no significant difference compared to those with normal skin(P＞0.05).Conclusion The increased expression of Bcl-6 and BNIP3 and the decreased expression of Bim may be involved in the abnormal apoptosis of epidermal keratinocytes in the pathogenesis of psoriasis vulgaris.
Keywords：Psoriasis vulgarisApoptosisBcl-6BimPUMABNIP3BNIP3L
Publication Date：2023-12-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 327-330 )