The efficacy and safety of the compound yufa anti-dandruff shampoo for the treatment of scalp seborrheic dermatitis

CHEN Xi; YIN Yue; WANG You-xue

doi:10.11786/sypfbxzz.1674-1293.20230506

Abstract：Objective To study the efficacy and safety of Yufa Anti-dandruff Shampoo,with antimicrobial peptides as the main ingredient,in the treatment of scalp seborrheic dermatitis.Methods Thirty patients with mild to moderate seborrheic dermatitis were enrolled and treated with the product once a day from D1 to D7,and every 2 days from D8 to D28.Follow-up was conducted on D0,D14 and D28.Clinical and dermoscopic photos were taken.The severity of dandruff was evaluated using the Adherent Scalp Flaking Score(ASFS),the skin lesion score of seborrheic dermatitis,and the dynamic pruritus score for the symptom of rash and itching,respectively.The patients also provided subjective scores of conscious symptoms and completed dermatology life quality index(DLQI).All adverse reactions during the study were documented.Results Dandruff was significantly reduced after using the shampoo.The average ASFS score decreased from 11.00±8.094 to 2.57±2.22(P<0.001),with an effective rate of 90%.Erythema and papules were relieved,and the score of lesion scale decreased from 1.67±0.61 to 0.57±0.68(P<0.001),with an effective rate of 76.7%.Pruritus symptoms were relieved,with the scale score decreasing from 1.83±0.46 to 0.73±0.69(P<0.001),with an effective rate of 76.7%.In addition,the subjective symptoms of scalp tingling,burning and greasy were also improved to varying degrees,and the DLQI score was significantly improved from 10.47±4.87 to 3.53±3.50(P<0.05).The product exhibited good safety,with only 3 subjects experiencing slight irritation in the eyes,which resolved on their own.Conclusion Yufa Anti-dandruff Shampoo improves the symptoms of dandruff,erythema lesions and itching in patients with seborrheic dermatitis,and demonstrates good safety.