Retrospective analysis of clinical and pathological diagnoses of 4 736 genital skin biopsy cases
CHEN Jin
MA Ying
FAN Xiao-yao
Abstract：Objective To analyze the disease constitution and clinicopathological consistency/inconsistency of genital skin biopsy cases.Methods A total of 4736 genital skin biopsy cases from January 2011 to December 2020 were collected from Huashan Hospital Affiliated to Fudan University,all stained with hematoxylin-eosin,and some underwent further immunohistochemical staining.We retrospectively studied the clinical and pathological diagnosis.Results Based on the pathological diagnoses,the cases were divided into 9 categories,encompassing more than 50 diseases.Condyloma acuminatum,Lichen sclerosus et atrophicus and extramammary Paget's disease were the most common diseases.The disease composition varied among different genders and age groups.The clinicopathological consistency rate was low,ranging from 0%(verrucous carcinoma,malignant melanoma)to 50.44%(extramammary Paget's disease).Immunohistochemical staining was performed on 1022 of all biopsies to establish definitive diagnosis.Conclusions Disease categories of genital diseases differed from those of other anatomical parts,and the diagnostic accuracy was significantly lower.It's necessary to improve the understanding of genital diseases and carry out skin biopsy to assist the diagnosis.
Keywords：Genital diseasesBiopsyPathological diagnosisClinical diagnosisImmunohistochemical staining
Publication Date：2023-10-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 257-261 )