Progress of extracellular vesicles in fungal-host interactions
ZHANG Yu
LIU Zhe
LV Sha
Abstract：Fungal infection is a serious global health problem.The incidence is increasing rapidly and is further complicated by the emergence of more virulent,drug-resistant strains.There is an urgent need to uncover the pathogenicity mechanisms of fungal pathogens and develop novel drugs that can exert potent antifungal activity and overcome resistance.Nevertheless,little is known about fungal-host interactions and how these pathogens can manipulate hosts.In the last decade,extracellular vesicles(EVs)have become a hot topic.EVs contain specific proteins,lipids,and nucleic acids that can be passed to other cells as signal molecules to alter their function and play a significant role in many aspects of cellular life including cell-to-cell communication,infection and cancer.However,it is just at the beginning of understanding the influence of EVs on fungal pathophysiology and host-pathogen interactions.This review summarize the current understanding of fungal extracellular vesicles,including the biogenesis,secretion and functions.This paper also discuss the way they may influence the human immune response in order to understand how EVs mediate host immune and non-immune responses to fungi in the context of the communication with specific hosts suggesting potential new avenues for antifungal therapies.
Keywords：Fungal infectionsExtracellular vesiclesHostImmune response
Publication Date：2023-08-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 230-234 )