The expression of interleukin-1 family cytokines in peripheral blood of condyloma acuminatum
WANG Jian-lei
ZHU Tian
HAN Yu
Abstract：Objective To detect the serum levels of interleukin(interleukin,IL)-1 family cytokines in the peripheral blood of patients with condyloma acuminatum(CA)and explore the possible role of IL-1 in the pathogenesis of CA.Methods Peripheral blood samples were collected from 30 CA patients and 20 healthy controls,respectively.The expression levels of serum IL-1 family cytokines in CA patients and healthy controls were detected by antibody array.Results The serum levels of IL-1β,IL-36α,IL-36β and IL-36γ in peripheral blood in CA patients were(0.22±0.21)pg/ml,(226.93±109.85)pg/ml,(1.74±0.66)pg/ml and(88.24±47.63)pg/ml,which were lower than those in peripheral blood of healthy controls(0.87±1.18)pg/ml,(310.51±160.22)pg/ml,(2.17±0.65)pg/ml and(179.86±158.58)pg/ml,respectively.The differences were statistically significant(all P＜0.05).The expression levels of IL-37 and IL-38 in peripheral blood serum of CA patients were(88.72±26.81)pg/ml and(706.79±442.77)pg/ml,which were higher than those in peripheral blood serum of healthy controls[(63.22±44.38)pg/ml and(417.66±350.05)pg/ml].The differences were statistically significant(all P＜0.05).Conclusion The expressions of IL-1β,IL-36α,IL-36β and IL-36γ in peripheral blood of CA patients were decreased,and the expressions of IL-37 and IL-38 were increased,suggesting that IL-1β,IL-36α,IL-36β,IL-36γ,IL-37 and IL-38 may play a role in the pathogenesis of CA.
Keywords：Condyloma acuminatumInterleukin-1 family cytokinesInterleukin-1βInterleukin-36Interleukin-37Interleukin-38
Publication Date：2023-08-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 214-216,234 )