Human-like collagen dressing in the adjunctive treatment of atopic dermatitis in children

SHEN Chun-ping; LIU Xiao-yan; WANG Liu-hui

doi:10.11786/sypfbxzz.1674-1293.20230401

Abstract：Objective To evaluate the efficacy and safety of human-like collagen dressing in the adjunctive treatment of mild-to-moderate atopic dermatitis(AD)in children.Methods A multicenter,randomized,double-blind,controlled clinical trial was conducted.A total of 80 children with AD were enrolled and randomly divided into 2 groups to be topically treated with 0.1% hydrocortisone ointments + human-like collagen(test group,n=40)and 0.1% hydrocortisone ointments + human-like collagen matrix(control group,n=40).The improvement of skin dryness,skin barrier function,severity of AD and quality of life were evaluated at baseline,1 week,2 weeks and 4 weeks, so was the incidence of adverse reactions. Results Analysis of full analysis set (FAS) data results were shown as follows: ① he skin dryness of all patients were obviously improved after treatment, the test group was superior to the control group (P < 0.001); ② The skin barrier function of the two groups were signifi cantly improved than baselines, especially the TEWL and hydration (P < 0.05); ③ The severity of skin lesions of all patients were reduced after treatment, while there were no signifi cant diff erence between the two groups (P > 0. 05); ④ The quality of life of children aged 1 to 6 years was signifi cantly improved after 4 weeks of treatment, the test group was better than that in the control group (P ≥ 0. 01); ⑤ The incidence of adverse events in the two groups was 13.2% and 7.7％, there was no signifi cant diff erence between them (P > 0.05), and no serious adverse reactions occurred. Conclusion Human-like collagen dressing was eff ective in relieving the skin dryness and restoring the function of skin barrier in mild children with AD. It maybe one of adjuvant therapy options for children with mild AD.