Polymorphisms of interleukin-23 receptor and its association with susceptibility to psoriasis vulgaris in Ningxia region
Abstract：Objective To analyze the association of interleukin-23 receptor(IL-23R) polymorphisms with the susceptibility to psoriasis vulgaris(PV) in Ningxia region. Methods Five single nucleotide polymorphisms(rs10489629, rs10889677, rs1495965, rs1343151, rs11209032) of IL-23R gene were genotyped by Taqman fluorescent PCR in 101 PV cases and 103 normal controls, and the data was statistically analyzed by Haploview 4.2 software. Results There was no significant difference in the allele frequency of SNP rs1495965, rs10489629, rs10889677, rs1343151 and rs11209032(P＞0.05) of IL-23R gene between PV patients and controls. There was a linkage disequilibrium between rs11209032 and rs1495965 SNPs(D'=0.957, r2=0.821) by Hardy-Weinberg test, further analysis revealed that there was also no significant difference in haplotype of rs11209032 and rs1495965(P＞0.05). Conclusion The susceptibility to PV seems not to be associated with the SNPs rs10489629, rs10889677, rs1495965, rs1343151 and rs11209032 of IL-23R gene in Ningxia region.
Keywords：PsoriasisvulgarisNingxia regionInterleukin-23RSingle nucleotide polymorphism
Publication Date：2018-01-01
Pages：4( 138-141 )