Research on the role of Nrf2 in photoaging
REN Jing
MA Liang-juan
Abstract：The skin may be directly affected by ultraviolet irradiation,and ultraviolet radiation can cause a variety of skin damage,including photoaging and a variety of skin cancer.Continuous cell photo-damage is the basis of skin aging.Studies have shown that:oxidative stress response induced by ultraviolet radiation in human skin,which results in the production of reactive oxygen species(ROS)is the main cause of cell light damage.Nrf2 plays an important defense role in many lesions associated with oxidative stress response.Nrf2 deletion or activation disorder increases the sensitivity of cells to ultraviolet radiation,and increases light damage and photoaging of cells.This paper reviews the important protective effects ofNrf2 gene on light damage and photoaging.
Keywords：Nrf2UltravioletPhotoagingReactive oxygen speciesOxidative stress
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 94-96,100 )