Study on the relationship between Malassezia furfur infection and serum inflammatory factors of the patients with psoriasis vulgaris
DENG Guo- hui
YANG Guo-liang
Abstract：Objective To study the relationship between Malassezia furfur antibody and serum inflammatory factors of the patients with psoriasis vulgaris.Methods From May 2014 to December 2015,serum anti Malassezia furfur soluble antigen(MA Sag),whole cell antigen (MA Wag) IgG, IgA, IgM and level of serum interleukin 8 (IL 8), tumor necrosis factor alpha (TNF alpha) and substance P (SP) were measured in 68 cases of psoriasis vulgaris(PV)and 35 healthy subjects(control group)by ELISA,and the relationship between Malassezia furfur antigen and serum inflammatory factors of PV was analyzed by Pearson correlation analysis.Results The detection values of anti Wag IgG level were as follow: PV advanced group (0.563±0.122), PV remission group (0.412±0.121) and control group (0.312±0.112), the serum anti Wag IgG level reduced gradually, the difference between every two groups was significant (P<0.05); the detection values of anti Sag IgM level were as follow: PV advanced group (0.098 ±0.012), PV remission group (0.096±0.010), both were higher than the control group (0.145±0.082), the difference between the groups was statistically significant (P<0.05); the detection values of serum factors were as follow: IL-8 (256.36±48.25), TNF-a (18.22±3.25) and SP (312.85±32.56) in PV advanced group; IL-8 (128.96±32.52), TNF-a (7.98± 2.45) and SP (285.69±30.48) in PV remission group; the level of serum inflammatory cytokines IL-8, TNF-a and SP all decreased in the control group compared with the two PV groups, the difference between the groups was significant (P<0.05). For the correlation analysis of Malassezia furfur antibody and serum inflammatory factors of the patients with psoriasis vulgaris,anti Wag IgG level was positively correlated to serum IL 8 (r=0.325), TNF alpha (r=0.318) and SP (r=0.332) (P<0.05); anti Sag IgM level was also positively correlated to serum IL-8(r=0.345),TNF alpha(r=0.326)and SP(r=0.337)(P<0.05).Conclusion Malassezia furfur infection and PV may have a close relationship,the mechanism may be associated with Malassezia furfur infection which may cause abnormal humoral immunity,inflammatory factors release and the concentration of inflammatory factors in skin lesions.
Keywords：PsoriasisvulgarisMalassezia furfurImmunityhumoralSerum inflammatory factors
Publication Date：2018-02-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 5-8 )