Effects of BAIBI capsules on psoriatic mice and its mechanism of action
ZHANG Qian
PENG Tao
SHI Hong-qiao
Abstract：Objective To investigate the effects of BAIBI capsules on mice models of psoriasis, including estrogen induced vaginal epidermis mouse model and mouse tails' model, and to explore its mechanism of action. Methods The induced vaginal epidermis mouse model was established by feeding the mouse with estrogen to facilitate the formation of their vaginal epidermis, meanwhile the mouse tails' model was built by using mouse tails that were born without stratum granulosum. BAIBI capsules of the different concentrations (0.72 g/kg, 0.36 g/kg), normal saline and MTX were given to mouse models for 14 days, then the mitotic index of the mouse's vaginal epithelia and the number of mouse-tails' granular flakes were evaluated. Results Compared with the control groups, each dose of the two medicine inhibited mouse vaginal epithelial mitosis(P<0.05), and the medicines also facilitated the formation of the granular layers in the flakes of the mouse-tails(P<0.05). Conclusion BAIBI capsules could help alleviate psoriasis through inhibiting mouse vaginal epithelial mitosis and facilitating the formation of the granular layers in the flakes of the mouse tails.
Keywords：PsoriasisBAIBI capsuleMitotic vaginal epithelial mitosisFormation of the granular layers
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 234-236,239 )