Expression and clinical significance of ALDH1, E-cad and uPAR in human melanoma
Abstract：Objective To study the expression of aldehyde dehydrogenase 1(ALDH1), E-cadherin(E-cad) and urokinase-type plasminogen activator receptor(uPAR) in melanoma tissues and their relationship with clinicopathological features. Methods A total of 50 lesions of melanoma and 50 lesions of nevus were selected as the research objects, and the expression of ALDH1, E-cad and uPAR were detected by immunohistochemical method, then the correlations between the expression of the three kinds of proteins, clinicopathological features, and tumor staging were analyzed. Results ALDH1 and uPAR positive expression rate of melanoma tissues were 82.00％ (41/50) and 86.00％ (43/50) respectively, which were significantly higher than that of pigmented nevus group (P<0.05); melanoma tissue E-cad positive expression rate was 38.00％ (19/50), which was significantly lower than that of pigmented nevus group (P<0.05). ALDH1, uPAR expression wasn't related to age, gender, tumor thickness, depth of invasion, lymph node metastasis and pathological classification, but for the melanoma tissues which tumor invasion depth over 4mm, depth of invasion ranged IV ～ V and lymph node metastasis occurred, the positive expression rate of ALDH1 and uPAR was above 90％. The positive expression rate of E-cad was significantly lower in patients with infiltrative depth ranged IV ～ V than that in patients with invasive depth ranged I ～ III (P<0.05), and the positive expression rate of E-cad was not associated with other clinical features. Conclusion The expression of ALDH1 and uPAR was up-regulated and the expression of E-cad was down-regulated during the development and progression of melanoma. The down-regulation of E-cad expression was related to the degree of tumor.
Keywords：MelanomaALDH1E-caduPAR
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 201-204 )