Effect of different doses and different formulations of glycyrrhizin preparations on skin patch test results of formaldehyde and nickel sulfate

doi:10.11786/sypfbxzz.1674-1293.20170306

Abstract：Objective To evaluate the effect of compound glycyrrhizin on skin patch test results of formaldehyde and nickel sulfate. Methods A total of 96 patients who showed moderate positive patch test reactions to nickel sulfate or formaldehyde were enrolled into this study. After the first patch test, the patients were treated with different doses and different dosage forms of glycyrrhizin in succession. Firstly, the patients were treated by middle-dose medicine for 2 weeks(compound glycyrrhizin glucoside piece, 50mg, tid, orally), then, the patients were treated by high dose the same medicine(compound glycyrrhizin glucoside piece, 75mg, tid, orally) for another 2 weeks, finally the patients were treated by the intravenous dosage form(glycosides compound glycyrrhizin injection, 60ml, qd, intravenous drip) for 1 week. The interval between every two courses was two months, and the patch test was repeated after every course, then the effect of the different doses and formulations of compound glycyrrhizin preparations on the patch test results of formaldehyde and nickel sulfate was analyzed. Results Totally, 92 patients completed the middle-dose compound glycyrrhizin intervention trial, repeated patch test results were as follow: 15 cases of weakly positive (+), 75 cases of strong positive (++), 2 cases of strong positive (+++) and no patient was negative. Significant differences were observed in the degree of reactivity (Z=-3.367, P=0.001). For the patch test results of the 89 patients who completed high dose intervention trial, 40 cases was weakly positive (+), 39 cases was strong positive (++), 10 cases was negative (-), reaction properties of qualitative results: Z=-5.792(P=0.000) and degree of reactivity:Z=-8.774(P=0.000). For the 59 patients who completed the intravenous injection intervention, repeated patch test results were as follow: 11 cases of weakly positive (+), 12 cases of strong positive (++), 36 cases were negative, reaction properties of qualitative results: Z=-8.024(P=0.000) and degree of reactivity: Z=-9.689(P=0.000). Conclusion Both high-dose oral compound glycyrrhizin and intravenous compound glycyrrhizin could evidently suppress skin patch test reactions of formaldehyde and nickel sulfate, and exert a certain clinical curative effect on the allergic contact dermatitis induced by the same substance.