Expression of Ki67 in scar carcinoma and its clinical significance

doi:10.11786/sypfbxzz.1674-1293.20170301

Abstract：Objective To investigate the expression of Ki67 in scar carcinoma tissues and its correlations with the clinical characteristics of the patients with scar carcinoma. Methods A total of 27 patients who had been pathologically diagnosed as scar carcinoma were enrolled in this retrospective study. The expression of Ki67 in scar carcinoma tissues from those 27 cases was measured by immunohistochemical method. The correlations between Ki67 protein expression and each relevant clinical characteristic were also analyzed. Results The detection rate of Ki67 protein in scar carcinoma tissues was 100% (27/27). According to the percentage of Ki67-positive cells, the patients were divided into three groups, i.e. ≤10% (10 cases), 11%~40% (10 cases) and ≥41% (7 cases). The percentage of Ki67-positive cells in scar carcinoma tissues was significantly associated with ulcer duration(P<0.05), depth of invasion(P<0.01) and post-operation recurrence(P<0.05). However, the expression of Ki67 was not correlated with scar duration and ulcer size in scar carcinoma tissues(P=0.082, P=0.401). Conclusion The expression of Ki67 in scar carcinoma tissues would provide a meaningful evidence for evaluating invasion depth and recurrence after operation.