Research progress on the role and mechanism of Nrf2/ARE in photoaging resistance
Abstract：Photoaging is a chronic injury that is caused by long term exposure to ultraviolet radiation. Previous research showed that oxidative stress damage was the main cause of acute or chronic inlfammation in the skin, even cell mutation, and UV irradiation is one of the most damaging factor to induce oxidative stress damage. Long term exposure to UV causes excessive ROS production, which is beyond the scavenging ability of our bodies. These ROS can affect the related signal pathway, lead to light aging and cancer. Recent studies reported that Nrf2(NF-E2, NF-E2 related factor 2) was the key factor involved in cell oxidative stress reaction. Nrf2 could combine the oxidation reaction of downstream components(antioxidant response element, ARE) and play an important role in cell defense protection, and then effectively resist skin damage caused by UV irradiation. This article was a review about the role of Nrf2/ARE in photoaging resistance and its related mechanism.
Keywords：Nrf2Antioxidant response elementReactive oxygen speciesPhotoagingUltraviolet
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 319-321 )