Association of vitamin D receptor gene single nucleotide polymorphism with human susceptibility to syphilis
Abstract：ObjectiveTo explore the association of vitamin D receptor (VDR) gene Fox I, Bsm I, Apa I and Tap I single nucleotide polymorphism with human susceptibility to syphilis.MethodsThe study recruited 106 patients with syphilis and 134 health volunteers as the normal control. The Fox I, Bsm I, Apa I and Tap I single nucleotide polymorphism of VDR gene were detected in all subjects by MassArray system.ResultsNo signiifcant difference was found in genotypic frequencies of the 4 SNPs (Fox I, Bsm I, Apa I and Tap I) between the two groups (Fox I:P=0.922; Bsm I:P=0.460; Apa I:P=0.287; Tap I:P=0.093). The allelic frequencies of these SNPs also showed no signiifcant difference between the two groups (Fox IC vs. T:P=0.742; Bsm IC vs. T:P=0.345; Apa IG vs. T:P=0.113; Tap I A vs. G:P=0.345). Furthermore, these 4 SNPs in the recessive model or dominant model showed no signiifcant difference between the two groups (Fox ICC vs. CT+TT:P=0.687; Fox I TT vs. CT+CC:P=0.905; Bsm ICC vs. CT+TT:P=0. 336; Apa I TT vs. GT+GG:P=0.438; Apa IGG vs. GT+TT:P=0.123; Tap I AA vs. AG+GG:P=0.204).ConclusionThe Fox I, Bsm I, Apa I and Tap I single nucleotide polymorphism of VDR gene may be not associated with the susceptibility to syphilis.
Keywords：SyphilisVitamin D receptor geneSingle nucleotide polymorphismGenetic susceptibility
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 293-295,299 )