Pathologic observation about the inlfuence of compound xiaoyin-ointment on psoriasis-like mice model

doi:10.11786/sypfbxzz.1674-1293.20160501

Abstract：ObjectiveTo observe the pathological changes of the psoriasis-like BALB/c mice model treated by compound xiaoyin-ointment.MethodsForty-eight mice were randomly divided into six groups: blank group, model group, compound xiaoyin-ointment treatment group A, compound xiaoyin-ointment treatment group B, clobetasol propionate treatment group, xiaoyin-ointment treatment group. 5% imiquimod was applied on the back of all mice except blank group to produce psoriasis-like mice model. All the groups except blank group and model group were treated with corresponding ointment for 8 days. Then pathological manifestations (BAKER score) were investigated under light microscope and statistical analysis were performed. ResultsThe difference of BAKER score between blank group and model group showed statistical significance(P<0.05), which indicated successful psoriasis-like mice model. Compared with model group, the BAKER scores of compound xiaoyin-ointment treatment group A, compound xiaoyin-ointment treatment group B and clobetasol propionate treatment group were lower with statistical significance(P>0.05). The difference of BAKER scores between clobetasol propionate treatment group and compound xiaoyin-ointment treatment group showed statistical signiifcance(P<0.05), but the differences between compound xiaoyin-ointment treatment group A and compound xiaoyin-ointment treatment group B showed no statistical signiifcance(P>0.05). The BAKER score of xiaoyin-ointment treatment group was lower than model group and higher than other three treatment groups with statistical signiifcance(P<0.05).ConclusionPsoriasis pathologic changes caused by imiquimod were remarkably improved after being treated with these four kind of ointments. For the efifcacy, the clobetasol propionate treatment group was the most obvious, the second was the compound xiaoyin-ointment treatment group, and the xiaoyin-ointment treatment group was the worst. However there were no signiifcant differences between compound xiaoyin-ointment treatment group A and compound xiaoyin-ointment treatment group B.