Advances in the research of immunoregulation of Rho GTPase/ROCK signaling pathway in dermatosis
ZHANG Li-ping
HE Yan-ling
Abstract：In the immunoregulation of skin vasculitis and dermatoma, the effect of Rho GTPase/ROCK signaling pathway is receiving more attentions in view of its moderating role on T cells. The pathway mainly affects cytoskeletal rearrangement and cell movement. Recent studies have indicated that Rho GTPase/ROCK pathway can inlfuence the adhesion, migration, stimulation and activation of T cells, and affect the immune response. Rho GTPase/ROCK pathway is involved in the pathogenesis of system lupus erythematosus, Behcet's disease and melanoma. Currently, Y27632 and Fasudil, the inhibitors of Rho GTPase/ROCK signaling pathway, have been put into clinical and basic research, which have achieved good results and may be the potential drugs in the treatment of the disease in the future. More and more evidences show that ROCK inhibitors play an important role in wound healing and scar contracture in recent years.
Keywords：Rho GTPase/ROCK signal pathwayT cellVasculitisdermalMelanoma
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 259-261 )