The neuro-endocrine-immune pathogenesis of vitiligo
Abstract：Vitiligo is an acquired depigmentary skin disorder characterized by well-demarcated, white macules. Despite relevant new research and progresses, why and how melanocytes disappear is not fully understood. In spite of recent ifndings implicated the disease is closely related to many factors, such as genetic, immune and oxidative stress factors, the exact pathogenesis of vitiligo remains obscure. An innovative concept based on a functional crosstalk between the nervous and immune system is emerging. Neuropeptides released from peripheral nerve endings could synergize new cytokines to disturb the immune microenvironment of skin. Evidence is increasing regarding the role of neuropeptides in the pathogenesis of vitiligo and a new winning approach of vitiligo therapy based on neuropeptides regulation is at the horizon.
Keywords：VitiligoNeuro-endocrineneuropeptidesImmunePathogenesis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 195-198 )