CLOVES syndrome
YIN Rui-rui
SUN Yu-juan
MA Lin
Abstract：CLOVES syndrome is a rare overgrowth syndrome manifested by congenital lipomatous overgrowth, vascular malformations, epidermal nevi, and skeletal/scoliosis/spinal anomalies, which was caused by postzygotic activating mutations of PIK3CA. The management is a rather complex, lengthy process requiring the experience of different specialties. The corresponding management is symptomatic. The continual evolving of molecular diagnosis enables the possibility of novel therapies targeting speciifc genes in the future. Long-term prognosis of the disease is still unclear.
Keywords：CLOVES syndromePIK3CA geneLipomaOver growthVascularmal formations
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 124-126 )