Photodynamic therapy with different concentrations of 5-aminolevulinic acid in the treatment of cystic acne
Abstract：ObjectiveTo investigate the optimal concentration of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for cystic acne.Methods Total 116 patients were randomly divided into 3 groups to be applied with ALA-PDT in different concentrations (5%, 7.5% and 10%). The patients were treated with red light of 632.8 nm once a week for 4 procedures. The subsidence of lesions was evaluated by dermatologist at the baseline and after half a month, 1 and 3 month of the last treatment. Adverse reactions were recorded at follow-up.ResultsHalf a month, one month and three months after the last treatment, there was no significant difference between 7.5% and 10% group (P>0.05). Compared with 5% group, there were signiifcant differences between the every two groups with the different concentrations(P<0.05). Side effects included erythema, swelling, a little of exudation and transient pigmentation. Neither ulceration nor scarring was noted.ConclusionIn view of effectiveness and safety, ALA with concentration of 7.5% is recommended for the treatment of cystic acne.
Keywords：Acnecystic5-aminolevulinic acid photodynamic therapy
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 112-114 )