The clinical observation of cultured autologous melanocytes transplantation in the treatment of vitiligo

doi:10.11786/sypfbxzz.1674-1293.20160110

Abstract：Objective To observe the therapeutic effect and influence factors of cultured autologous melanocytes to transplantation in the treatment of vitiligo. Methods To observe the therapeutic effect and influence factors of cultured autologous melanocytes transplantation in the treatment of vitiligo. Methods Seventy-eight patients with stable vitiligo were enrolled in the study, and the autologous melanocytes cultured in vitro were transplanted onto the depigmented areas of the vitiligo patients. The therapeutic effect and complications were observed, and the influence factors were analyzed. Results The patients had total 189 depigmented lesions. The repigmentation up to 90% or more was seen in 51.85% of the lesions, and the repigmentation over 50% was seen in 79.89% of the lesions. The effective rate of the segmental group was 86.04%, which is better than localized group and generalized group, respectively. A higher cure rate was also seen in patients with facial lesions. The effective rate in patients of DOT≤3.5 d was significantly higher than the patients of DOT>3.5 d (P<0.05). Conclusion Transplantation of autologous cultured melanocytes is effective in the treatment of stable vitiligo. The therapeutic efficacy is related to types of vitiligo, locations of lesions and melanocytes biologic activity.