Clinical trail on safety and efficacy of an injectable cross-linked sodium hyaluronate gel for moderate and severe nasolabial groove
Abstract：Objective To investigate safety and efficacy of yishumei?—a injectable cross-linked sodium hyaluronate gel on alleviating moderate and severe nasolabial groove. Methods A randomized, single-blind, parallel controlled study was conducted on selected volunteers with moderate and severe nasolabial groove. Restylane? Ⅱor yishumei?(<1.5 ml) was injected either side to correct nasolabial groove. Bilateral nasolabial wrinkle severity rating scale (WSRS) and adverse events were evaluated by surgeon and volunteers independently at preoperative and immediately, 4 weeks, 12 weeks, 24 weeks after procedure. SPSS13.0 software was used for statistical analysis. Results The average age of 30 selected volunteers (28 female, 2 male) was 45.8. Bilateral nasolabial WSRS declined after procedure, and the difference between WSRS of immediately and of 24 weeks later has no statistically significance (P>0.05). Two cases of adverse events (2/30, 6.67%) occurred during the test, and one case thought to be related to the research materials. Conclusion Yishumei? injectable cross-linked sodium hyaluronate gel has consistent efficacy and safety with restylane?Ⅱ on alleviating moderate and severe nasolabial groove.
Keywords：Wrinklenasolabial grooveSodium hyaluronate gelClinical trail
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 20-23 )