The influence of combined application of immunomodulator on the asymptomatic shedding and serum IL-2, IL-4 levels of subclinical GH guinea pig model
Abstract：Objective To observe the detoxification and immunity status of subclinical genital herpes(GH) guinea pig model which accepted combined treatment of pidotimod tablets and pseudomonas aeruginosa injection, so as to reveal the effect of administration of immunomodulator in patients with subclinical GH. Methods GH guinea pig model was gained by using HSV-2 sav to infect female guinea pig which had never been infected by HSV, polymerase chain reaction (PCR) was used to detect the HSV-DNA of guinea pig genital and genital tract swab, and enzyme-linked immunosorbent assay (ELISA) was adopted to detect the concentration of serum IL-2 and IL-4(pg/ml). Finally the data of the different groups were analyzed and compared. Results Guinea pigs model of subclinical GH shedding HSV was confirmed, and the serum IL-2 levels of subclinical GH guinea pig model group was significantly lower than that of blank control group (P<0.01), IL-4 levels of subclinical GH guinea pigs model group was higher than that of blank control group (P<0.05). The HSV-DNA positive rate of medication group decreased significantly, and the serum IL-2 levels of medication group was higher than that of subclinical GH guinea pigs model group, the serum IL-4 levels of medication group was lower than that of subclinical GH guinea pigs model group, and the difference was statistically significant (P<0.05). Conclusion The guinea pig model of subclinical GH shedding HSV was confirmed and the secretion of serum cytokine became abnormality. Combined application of pidotimod and pseudomonas aeruginosa injection can reduce HSV shedding and improve immune imbalance.
Keywords：Herpes genitalsubclinicalPidotimodPseudomonas aeruginosaHSVIL
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 12-14 )