Clinical efifcacy of antimicrobial peptide combined with hyaluronic acid in the treatment of moderate acne vulgaris
Abstract：ObjectiveTo evaluate the efifcacy and tolerability of two new products contain antimicrobial peptides and hyaluronic acid in the treatment of moderate acne vulgaris.MethodsThirty patients with moderate acne vulgaris, according to Pillsbury classiifcation, were enrolled. The combined treatment was given to the subjects consistently for 28 days. All subjects were followed-up on 7, 14 and 28 days. The lesion count, IGA score and subject’s satisfaction were collected on each follow-up, as well as taking photos with VISIA, melanin index, erythema index and TWEL measurements. The adverse events were also observed.ResultsThe number of inflammatory lesions and total lesions were significantly reduced after 14 days treatment (P<0.05). IGA score also decreased, which was 1.958±0.55 on day 28 vs. 2.125±0.338 on day 0 (P<0.05). The erythema index and porphyrin values were also signiifcantly reduced at day 28 compared with baseline (P<0.05). Only one subject showed intolerance to the mask, who was considered to be sensitive skin and the reaction was not related to the product.ConclusionThe new products contain antimicrobial peptides and hyaluronic acid can be used safely and effectively in moderate acne vulgaris patients.
Keywords：Acne vulgarisAntimicrobial peptidesHyaluronic acid
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 340-344 )