Efifcacy and safety of acitretin in the treatment of 18 children with generalized pustular psoriasis
Abstract：ObjectiveTo investigate the efifcacy, side effects and safety of oral acitretin in the treatment of childhood generalized pustular psoriasis.MethodsEighteen cases of generalized pustular psoriasis who hospitalized in the Department of dermatology of Beijing Children’s Hospital were collected. The efficacy and safety of acitretin were analyzed retrospectively.ResultsThe treatment of Acitretin was considered to be effective in all cases. Clinical cure achieved in 50% cases in the ifrst month of treatment. The most common adverse effects were itch and mucocutaneous effects that presented in 77.8% patients during treatment, followed by hepatotoxicity(33.3%), hyperlipidemia(33.3%), paronychia(16.7%) and alopecia(5.6%), no skeletal system abnormalities were found during the follow-up period. The most common predisposing factor of recurrence was infection.ConclusionAs monotherapy, Acitretin is effective and safe for pediatric generalized pustular psoriasis and can be used as the ifrst choice treatment of the disease.
Keywords：PsoriasispustulargeneralizedAcitretinChildren
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 321-323 )