The role of regulatory T cells in allergic contact dermatitis
ZHAO Li
LI Lin-feng
Abstract：Regulatory T cells (Tregs) are a subset of T cells with immunoregulation activities. Recent studies have found that Tregs, apart from CD4+CD25+Foxp3+Tregs, play strong immunosuppression effects in the maintenance of self-tolerance and immune homeostasis, mainly by acting on effector cells and antigen presenting cells (APC) through multiple immunoregulatory pathways. Allergic contact dermatitis (ACD) is a common inflammatory skin disease, and also referred to as cutaneous hypersensitivity, is mediated by antigen-speciifc T cells. Tregs take an important part in allergic contact dermatitis, including preventing a weak hapten-induced contact dermatitis and reducing a strong hapten-induced cutaneous inlfammation reaction.
Keywords：DermatitiscontactallergicT cellsregulatoryCutaneous hypersensitivityImmunity
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 201-204 )