Distribution and drug susceptibility analysis of 290 strains of deep fungal infections

doi:10.11786/sypfbxzz.1674-1293.20150302

Abstract：Objective To investigate the condition of deep fungal infection, the infection type of pathogen and the sensitivity of the common antifungal drugs. Methods A total of 31 305 blood and aseptic body lfuids specimens of hospitalized patients from Jan 2012 to Apr 2014 were collected, then the isolated and cultured fungi were identiifed by microscopy, CHRO mager medium and VITEK-32 microbe automatic system. The clinical conditions were analyzed and the drug susceptibility was determined by disc diffusion method. Results Totally 290 strains(0.92%) were isolated. The detection rate of the fungal infection in blood was the highest with 41.03%, secondly was the urine with 21.38%. Many specimens came from general surgery department(55.82%). The strains were constituted with Candida albicans (31. 03%), C.tropicalis(17.93%), C.glabrata(17.59%) and C.parapsilosis(13.10%). Candida albicans and C.parapsilosis were relatively sensitive to zoles. All the four common fungus were sensitive to Amphotericin and Flucytosine. Conclusion Specimens of fungi detected in blood were with the highest constituent ratio, and the distribution of fungal infection in general surgery patients was highest. Candida is the major pathogen which caused deep fungal infection in hospital, especially the C.albicans with the highest infection rate. The drug resistance rates of Amphotericin and Flucytosine are the lowest, while the rate of Fluconazole is the highest. The drug resistance presents a genus difference.