Comparative study of photodynamic therapy with different concentration aminolevulinic acid in the treatment of generalized recalcitrant facial verruca plana：a randomized clinical trial
Abstract：ObjectiveTo investigate the efficacy and safety of topical photodynamic therapy (PDT) with different concentrations of photosensitiser in the treatment of verruca plana.MethodsThe two sides of a subject’s face were separately randomized to receive aminolevulinic acid (ALA) of 5%, 10% or 20% concentration. All patients were irradiated with 633 nm red light for 339 J/cm2 total dose. Complete response (CR) rate was assessed on week 4, 8, and 12 respectively.ResultsThe mean overall clearance rate was 74.1%, 68.8%, and 64.6% on week 4, 8, and 12, respectively, in the 110 treated sides. The CR rate of the 5%-ALA group was lower than the 10%-ALA group (14.3% vs. 33.3%, P<0.05) and the 20%-ALA group (14.3% vs. 33.3%,P<0.05) and 20%-ALA group (14.3% vs. 26.3%,P<0.05) after 12 weeks. The mean severity of pain measured by visual analogue scale (VAS) scoring was 3.8 (range: 2 to 10, depending on the lesion location). The overall recurrence rate was 16.7% (4/24) on week 12. Hyperpigmentation was observed in 69.8% (67/96) of all treated sides. On week 4, 8, and 12, hyperpigmentation was more developed in the 20%-ALA group than in the other two groups (P<0.05). ConclusionsThis randomized clinical trial suggests that PDT with ALA of 10% concentration offers better efifcacy and safety than 5% or 20% concentration for generalized recalcitrant facial verruca plana.
Keywords：Verruca planafacialAminolevulinic acidPhotodynamic therapy
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 95-98 )