The clinical features and prognosis of subcutaneous panniculitis-like T-cell lymphoma
Abstract：ObjectiveTo analyze the clinical characteristics, treatment and prognosis related factors of subcutaneous panniculitis like T cell lymphoma (SPTCL).MethodsTotal 192 patients of SPTCL reported in the literatures in China were included by searching Wanfang and CNKI databases with the keywords of "subcutaneous panniculitis", "T-cell lymphoma" and "lymphoma", then the clinical characteristics, treatments and follow-up results were analyzed.ResultsThere were roughly equal numbers of male and female patients reported (n=95 andn=97, respectively). The median age at diagnosis was 34 years (range, 1.5-82years). The skin lesions predominantly affect the extremities (54%) and trunk (36%), but can also occur on face and buttocks. Most neoplastic lymphocytes expressed CD3, CD45 and CD45RO. At the time of diagnosis, hemophagocytic syndrome (HPS) was reported in 81 of 192 patients (42%). The presence or absence of HPS, as well as the presence or absence of B symptoms may led to signiifcant difference in prognosis (P=0.001 andP=0.006, respectively).ConclusionSPTCL is a rare subtype of primary cutaneous lymphoma which has unique clinical features. The presence of HPS or B symptoms may indicate a poor prognosis.
Keywords：LymphomaT-cellsubcutaneous panniculitis-likeClinical characteristicsHPSRetrospective analysis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 417-419,422 )