Research progress on microRNAs’ role in the pathogenesis of systemic lupus erythematosus
TANG Qian
YANG Yang
LU Qian-jin
Abstract：Systemic lupus erythematosus (SLE) is a chronic, multi-system autoimmune disease characterized by disorder of the generation of auto-antibodies to components of cell nucleus. MicroRNAs (miRNAs), as post-transcriptional regulatory factor of gene expression have been attracting more and more attention. Accumulating evidence indicates that miRNAs play a pivotal role in the pathogenesis of SLE. In this article, we discuss the regulatory roles of miRNAs in T cell DNA methylation, regulatory T-cells, B cells, type I interferon pathway, and X-linked genes in the pathogenesis of SLE.
Keywords：Lupus erythematosussystemicMicroRNAsPathogenesis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 367-369 )